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  1. Cell
    DYSREGULATION OF MITOCHONDRIAL CLPP
    PROTEASE AS A POTENTIAL STRATEGY TO
    DEVELOP NOVEL ANTICANCERS
    Human mitochondrial ClpP was found to be activated by specific
    acyldepsipeptide compounds causing apoptotic cell death.
    Houry and Batey groups, Cell Chemical Biology, 2018
  2. Nature
    AMINE HEMILABILITY ENABLES BORON TO
    MECHANISTICALLY RESEMBLE EITHER
    HYDRIDE OR PROTON
    Mechanistic studies of the hemilability of MIDA
    (N-methyliminodiacetic acid) boronates reveal the chameleonic
    behaviour of the BMIDA group.
    Yudin group, Nature Chemistry, 2018
  3. Nature
    TIPPING CELL SIGNALING PATHWAYS BY SALTS
    Mechanistic insights into allosteric regulation ofthe A2A adenosine
    G protein-coupled receptor byphysiological cations.
    Prosser group, Nature Communications, 2018
  4. Journal of the American Chemical Society
    COMPETITIVE SELF-ASSEMBLY KINETICS AS A
    ROUTE TO CONTROLLING MORPHOLOGY OF
    CORE-CRYSTALLINE CYLINDRICAL MICELLESS
    One can manipulate the seeded-growth kinetics of block
    copolymer unimers to control the growth sequence of
    unimers and thus the comicelle morphology.
    Winnik group, Journal of the American Chemical Society, 2018
  5. Oncogene
    INHIBITING MYC BINDING TO THE E-BOX DNA
    MOTIF BY ME47 DECREASES
    TUMOUR XENOGRAFT GROWTH
    The Shin lab's designed protein ME47 decreased tumor growth in
    a triple negative breast cancer mouse model, a type of cancer with
    no effective treatments.
    Shin, Chan & Penn groups, Oncogene, 2017

Awards:

Professor Mark Taylor wins Horace S. Isbell Award

Professor Mark Taylor wins Horace S. Isbell Award

Professor Mark Taylor is the winner of the 2018 Horace S. Isbell Award for excellence in and promise of continued quality of contribution to research in carbohydrate chemistry and biochemistry.

Mark is being recognized for his research in carbohydrate chemistry, particularly his work in developing catalysts that are able to activate sugars towards reactions at specific positions. These catalysts can be used to streamline the synthesis of complex, sugar-containing molecules.


News and Announcements:

Polanyi Group advances ability to control chemical reactions

Polanyi Group advances ability to control chemical reactions

Scientists at the University of Toronto have found a way to select the outcome of chemical reactions by employing an elusive and long-sought factor known as the ‘impact parameter’.

The team of U of T chemists, led by Nobel Prize-winning researcher John Polanyi, have found a means to select the impact parameter or miss-distance by which a reagent molecule misses a target molecule, thereby altering the products of chemical reaction.


Professor Mark Lautens: What is the future of STEM in the age of disruptive technologies?

Professor Mark Lautens: What is the future of STEM in the age of disruptive technologies?

Professor Mark Lautens writes in the Globe and Mail about the value of STEM in a world of disruptive technologies.

“When I examine how the careers of my former students have unfolded, it only reinforces my belief in the value of a STEM PhD in withstanding the winds of change over the course of a 30-40 year career,” says Lautens.



From poetry to chemistry: Professor Eugenia Kumacheva

From poetry to chemistry: Professor Eugenia Kumacheva

Professor Eugenia Kumacheva spoke with Intermission Magazine about her path to chemistry. Kumacheva, an avid poet in the Ukraine, once had aspirations of becoming a journalist until the world of science drew her in.

"My friends ask me now, ‘Where’s your poetry?” and I say, ‘My poetry is in my proposals.’



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Acyldepsipeptide Analogs Dysregulate Human Mitochondrial ClpP Protease Activity and Cause Apoptotic Cell Death
Acyldepsipeptides (ADEPs) are potential antibiotics that dysregulate the activity of the highly conserved tetradecameric bacterial ClpP protease, leading to bacterial cell death. Here, we identified...

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