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  1. DNA
    PROTEIN DIMERIZATION PARTNERS ARE DICTATED
    BY THE DNA TARGET, NOT PROTEIN TARGET
    Many genes are regulated by protein hetero- or homodimers. Shin et
    al found that DNA bases outside the protein-DNA recognition target
    determine the protein dimerization partner.
    Shin Group, Molecular Biosystems, January 2017
  2. THE ROLE OF DIMER ASYMMETRY AND
    PROTOMER DYNAMICS IN ENZYME CATALYSIS
    Prosser and coauthor Pai examine a homodimeric enzyme, fluoroacetate
    dehalogenase, which converts a highly toxic pesticide into a harmless
    metabolite, and explore the role of enzyme dynamics in the process.
    Prosser Group, Science, January 2017
  3. Graphical depiction of overall 2D scheme of coated gold microelectrode.
    BIOFOULING-RESISTANT [K+]o SENSOR
    FOR MONITORING EPILEPSY
    A novel approach for in vivo spatio-temporal measurements of [K+]o
    using multichannel monolayer coated gold microelectrodes reveals
    new physiological events not previously seen during seizures in mice.
    Thompson Group, Biosensors, December 2016
  4. SOLAR POWERED REVERSE WATER
    GAS SHIFT REACTION
    The role of defects on the electronic & photocatalytic properties of
    In2O3-x(OH)y NPs for the reverse water-gas shift reaction are revealed,
    a key advance towards efficient catalysts for the CO2 reduction reaction.
    Ozin Group, PNAS, December 2016
  5. Macrocyclization reaction between a linear peptide, an aldehyde and (N-isocyanimino)triphenylphosphorane.
    OXADIAZOLE GRAFTS IN PEPTIDE
    MACROCYCLES
    A new macrocyclization reaction delivers cyclic molecules for
    exploration in drug discovery.
    Yudin Group, Nature Chemistry, December 2016
  6. Figure showing a high degree of bond-selectivity dependent on adsorbate bond alignment.
    BOND SELECTIVE REACTION
    Kelvin Anggara, Kai Huang and Lydie Leung in Polanyi's group
    have shown and explained a hundredfold bond-selectivity in
    electron-induced reaction at a smooth metal surface.
    Polanyi Group, Nature Communications, December 2016
CSC 2017

Awards:

We are pleased to announce that Dr. David Petrone is the winner of the 2017 Chair’s Doctoral Medal. David obtained his Ph.D. in 2016 under the direction of Professor Mark Lautens. The title of his thesis is “Stereoselective Heterocycle Synthesis via Alkene Difunctionalization: Bulky Phosphine Ligands Enable Pd-Catalyzed Arylhalogenation, Arylcyanation and Diarylation”.

As undergraduates, some of the earliest organic reactions we encounter are addition reactions to alkenes. In his thesis, David describes the development of transition metal catalyzed synthetic methods that achieve novel functionalization of alkenes. The methods David has developed can now be applied in the synthesis of complex molecules.


News and Announcements:

Prof. Ronald Kluger wins 2017 Vivek Goel Faculty Citizenship Award

Prof. Ronald Kluger wins 2017 Vivek Goel Faculty Citizenship Award

Congratulations to Prof. Ronald Kluger on being honoured as one of this year’s Vivek Goel Faculty Citizenship Award recipients. This award recognizes senior faculty members who have been exemplary university citizens and have worked to fulfil the university’s academic mission. Ronald served as the inaugural Associate Chair for Graduate Studies at the Department of Chemistry and was instrumental in the creation of the Chemistry Club and the Awards Committee.

 

 


Prof. Lewis Kay is one of five 2017 Gairdner International Award winners!

Prof. Lewis Kay is one of five 2017 Gairdner International Award winners!

We are thrilled to announce that Prof. Lewis Kay is one of five 2017 Gairdner International Award winners. The Gairdner Award is one of the top international prizes recognizing biomedical research. Prof. Kay is being honoured for his work on "the development of modern NMR spectroscopy for studies of biomolecular structure dynamics and function, including applications to molecular machines and rare protein conformations." His contributions in this area have been ground-breaking and have allowed for the study of complex protein systems using NMR. Congratulations on this remarkable achievement, Lewis!

 

 

 

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