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  1. Oncogene
    INHIBITING MYC BINDING TO THE E-BOX DNA
    MOTIF BY ME47 DECREASES
    TUMOUR XENOGRAFT GROWTH
    The Shin lab's designed protein ME47 decreased tumor growth in
    a triple negative breast cancer mouse model, a type of cancer with
    no effective treatments.
    Shin, Chan & Penn groups, Oncogene, 2017
  2. DNA
    PROTEIN DIMERIZATION PARTNERS ARE DICTATED
    BY THE DNA TARGET, NOT PROTEIN TARGET
    Many genes are regulated by protein hetero- or homodimers. Shin et
    al found that DNA bases outside the protein-DNA recognition target
    determine the protein dimerization partner.
    Shin Group, Molecular Biosystems, January 2017
  3. THE ROLE OF DIMER ASYMMETRY AND
    PROTOMER DYNAMICS IN ENZYME CATALYSIS
    Prosser and coauthor Pai examine a homodimeric enzyme, fluoroacetate
    dehalogenase, which converts a highly toxic pesticide into a harmless
    metabolite, and explore the role of enzyme dynamics in the process.
    Prosser Group, Science, January 2017
  4. Graphical depiction of overall 2D scheme of coated gold microelectrode.
    BIOFOULING-RESISTANT [K+]o SENSOR
    FOR MONITORING EPILEPSY
    A novel approach for in vivo spatio-temporal measurements of [K+]o
    using multichannel monolayer coated gold microelectrodes reveals
    new physiological events not previously seen during seizures in mice.
    Thompson Group, Biosensors, December 2016
  5. SOLAR POWERED REVERSE WATER
    GAS SHIFT REACTION
    The role of defects on the electronic & photocatalytic properties of
    In2O3-x(OH)y NPs for the reverse water-gas shift reaction are revealed,
    a key advance towards efficient catalysts for the CO2 reduction reaction.
    Ozin Group, PNAS, December 2016
  6. Macrocyclization reaction between a linear peptide, an aldehyde and (N-isocyanimino)triphenylphosphorane.
    OXADIAZOLE GRAFTS IN PEPTIDE
    MACROCYCLES
    A new macrocyclization reaction delivers cyclic molecules for
    exploration in drug discovery.
    Yudin Group, Nature Chemistry, December 2016
  7. Figure showing a high degree of bond-selectivity dependent on adsorbate bond alignment.
    BOND SELECTIVE REACTION
    Kelvin Anggara, Kai Huang and Lydie Leung in Polanyi's group
    have shown and explained a hundredfold bond-selectivity in
    electron-induced reaction at a smooth metal surface.
    Polanyi Group, Nature Communications, December 2016

Awards:

Professor Dwight Seferos wins Harry Gray Award

Professor Dwight Seferos wins Harry Gray Award

We are pleased to announce that Prof. Dwight Seferos is the recipient of the 2018 Harry Gray Award for Creative Work in Inorganic Chemistry by a Young Investigator.

Dwight has been recognized for his development of tellurophene polymers and photoactive compounds and the profound impact he has had in multidisciplinary inorganic chemistry. Dwight’s synthesis of previously unknown compounds has contributed significant new knowledge in chemistry that will be important for meeting long-term challenges in energy.


News and Announcements:

Welcome to Our Incoming Graduate Students of 2017


Welcome to Our Incoming Graduate Students of 2017

We are excited to welcome our 75 incoming graduate students who will be pursuing their research interests at our UTM (Mississauga), UTSc (Scarborough) and St. George (downtown) campuses. (photo by Armando Marquez)

 

What Makes a Super Doctoral Supervisor?

What Makes a Super Doctoral Supervisor?

Like most successful relationships, partnerships between doctoral students and their supervisors are a matter of finding the right fit. A good match is important: supervisors and doctoral students work together for at least five years, longer than many people stay in a job. For some graduate students, Professor Mark Lautens, is that model supervisor.

Read more.

 

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A Radical Mechanism for Frustrated Lewis Pair Reactivity
The featured work targeted the accepted mechanism of FLP reactivity which involves the polarization of a substrate molecule in the pocket of an “encounter complex” leading to heterolytic cleavage. T...

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