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  1. DNA
    PROTEIN DIMERIZATION PARTNERS ARE DICTATED
    BY THE DNA TARGET, NOT PROTEIN TARGET
    Many genes are regulated by protein hetero- or homodimers. Shin et
    al found that DNA bases outside the protein-DNA recognition target
    determine the protein dimerization partner.
    Shin Group, Molecular Biosystems, January 2017
  2. THE ROLE OF DIMER ASYMMETRY AND
    PROTOMER DYNAMICS IN ENZYME CATALYSIS
    Prosser and coauthor Pai examine a homodimeric enzyme, fluoroacetate
    dehalogenase, which converts a highly toxic pesticide into a harmless
    metabolite, and explore the role of enzyme dynamics in the process.
    Prosser Group, Science, January 2017
  3. Graphical depiction of overall 2D scheme of coated gold microelectrode.
    BIOFOULING-RESISTANT [K+]o SENSOR
    FOR MONITORING EPILEPSY
    A novel approach for in vivo spatio-temporal measurements of [K+]o
    using multichannel monolayer coated gold microelectrodes reveals
    new physiological events not previously seen during seizures in mice.
    Thompson Group, Biosensors, December 2016
  4. SOLAR POWERED REVERSE WATER
    GAS SHIFT REACTION
    The role of defects on the electronic & photocatalytic properties of
    In2O3-x(OH)y NPs for the reverse water-gas shift reaction are revealed,
    a key advance towards efficient catalysts for the CO2 reduction reaction.
    Ozin Group, PNAS, December 2016
  5. Macrocyclization reaction between a linear peptide, an aldehyde and (N-isocyanimino)triphenylphosphorane.
    OXADIAZOLE GRAFTS IN PEPTIDE
    MACROCYCLES
    A new macrocyclization reaction delivers cyclic molecules for
    exploration in drug discovery.
    Yudin Group, Nature Chemistry, December 2016
  6. Figure showing a high degree of bond-selectivity dependent on adsorbate bond alignment.
    BOND SELECTIVE REACTION
    Kelvin Anggara, Kai Huang and Lydie Leung in Polanyi's group
    have shown and explained a hundredfold bond-selectivity in
    electron-induced reaction at a smooth metal surface.
    Polanyi Group, Nature Communications, December 2016
CSC 2017

Awards:

Congratulations to Profs. Jamie Donaldson and Myrna Simpson who have both received UTSC Faculty Research Awards for their outstanding research records in the area of environmental chemistry.

Prof. Jamie Donaldson is the recipient of the UTSC Principal's Research Award, which recognizes and encourages the research activities and achievements of senior professorial faculty members at UTSC.

Prof. Myrna Simpson has been selected as one of three UTSC Research Excellence Faculty Scholars, which recognizes outstanding and innovative world class researchers whose accomplishments have made a major impact in their fields.

Congratulations, Jamie and Myrna!


News and Announcements:

Prof. Lewis Kay is one of five 2017 Gairdner International Award winners!

Prof. Lewis Kay is one of five 2017 Gairdner International Award winners!

We are thrilled to announce that Prof. Lewis Kay is one of five 2017 Gairdner International Award winners. The Gairdner Award is one of the top international prizes recognizing biomedical research. Prof. Kay is being honoured for his work on "the development of modern NMR spectroscopy for studies of biomolecular structure dynamics and function, including applications to molecular machines and rare protein conformations." His contributions in this area have been ground-breaking and have allowed for the study of complex protein systems using NMR. Congratulations on this remarkable achievement, Lewis!

 

 

 


Using new NMR technique, U of T Scarborough researchers to monitor impacts of environmental contaminants at the molecular level

Using new NMR technique, U of T Scarborough researchers to monitor impacts of environmental contaminants at the molecular level

Professor André Simpson is leading a new collaboration funded by the NSERC Strategic Partnership Grant Program to examine the impacts of environmental contaminants at the molecular level and explain why it is toxic.

Partnering with both Professor Aaron Wheeler, who developed the digital microfluidics-microcoil NMR technology that the team will use, and Bruker BioSpin, Simpson's team will examine the complete molecular makeup of contaminants and interpret how specific molecules affect living organisms in real time.

Photo by Ken Jones

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The DNA target determines the dimerization partner selected by bHLHZ-like hybrid proteins AhRJun and ArntFos
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