Professor Jik Chin:
email
Texts - Recommended - Carey and Sundberg, Advanced Organic Chemistry, Part A, Fourth edition and Silverman - The Organic Chemistry of Enzyme-Catalyzed Reactions
Readings and Slides (email to RK or come to class for your password...)
Topics:
(RK): Mechanisms of organic reactions, especially in
water, and their application to enzyme reactions.
Review: Principles of reaction mechanisms and stereochemistry (Carey and Sundberg, Chapters 2 and 4)
Functional group interactions - carboxyls, amides, and anhydrides
Stereochemistry in chiral environments
Enolates - how do they form on enzymes?
Enzyme reaction principles - decarboxylation as a "simple" reaction
Phosphate transfer reactions: reactivity, intermediates and stereochemistry
Coenzymes: their problems and solutions
Thiamin as a catalyst and TDP as a coenzyme
Biotin, ATP and carboxylation
Additional topics...
(JC):Chirality in organic catalysis and recognition. Mechanisms and designs.
Marking Scheme:
As a core course, the emphasis will be on the application of principles
and methods. There will be one final exam (60 %), and critical reviews
(2 @ 20%) of journal articles that relate to
material in each part of the course. The critical reviews will be due
before the final exam.
Schedule: RK will teach from Jan.
10 through Feb. 14. JC will teach the rest of the term. The date of the exam will be scheduled during the semester.