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Kagan Kerman

Kagan Kerman

Academic Title: Associate Professor

Phone: 416-287-7249

Office: SW533

Email:

Research Homepage: http://www.utsc.utoronto.ca/~kkerman/index.htm

Research

Our research focuses on the analytical detection of biological events on surfaces. Observing the effect of small molecules on nucleic acids and cells is of particular interest. Nanoparticles conjugated with biomolecules enable us to monitor the recognition events using electrochemical (voltammetry) and spectroscopic (localized surface plasmon resonance) techniques. The modification of carbon, gold and mercury surfaces with nanoparticles and biomolecules is carried out to obtain innovative biosensing schemes. Our research involves aspects of diverse disciplines ranging from surface science, electronics and molecular biology to materials science and nanotechnology.

Selected Publications

1. H. Song, K. Kerman, H.-B. Kraatz, Electrochemical detection of kinase-catalyze phosphorylation using ferrocene-conjugatd ATP, Chem. Commun. 2008, 502-504.

2. K. Kerman, K. A. Mahmoud, H.-B. Kraatz, An electrochemical approach for the detection of HIV-1 protease. Chem. Commun. 2007, 3829-3831.

3. K. Kerman, M. Vestergaard, N. Nagatani, Y. Takamura, E. Tamiya, Electrochemical genosensor based on peptide nucleic acid-mediated PCR and asymmetric PCR techniques: Electrostatic interactions with a metal cation. Anal. Chem. 2006, 78, 2182-2189.

4. K. Kerman, Y. Morita, Y. Takamura, E. Tamiya, K. Maehashi, K. Matsumoto, Peptide nucleic acid-modified carbon nanotube field-effect transistor for ultra-sensitive real-time detection of DNA hybridization. Nanobiotechnol. 2005, 1, 65-70.

5. K. Kerman, M. Saito, Y. Morita, Y. Takamura, M. Ozsoz, E. Tamiya, Electrochemical coding of single nucleotide polymorphisms by monobase modified gold nanoparticles. Anal. Chem. 2004, 76, 1877-1884.

6. K. Kerman, D. Ozkan, P. Kara, A. Erdem, B. Meric, P. E. Nielsen, M. Ozsoz, Label-free bioelectronic detection of point mutation by using peptide nucleic acid probes. Electroanalysis 2003, 15, 667-670.

7. K. Kerman, D. Ozkan, P. Kara, B. Meric, J. J. Gooding, M. Ozsoz, Voltammetric determination of DNA hybridization using Methylene Blue and self-assembled alkanethiol monolayer on gold electrodes. Anal. Chim. Acta 2002, 462, 39-47.

8. K. Kerman, B. Meric, D. Ozkan, P. Kara, A. Erdem, M. Ozsoz, Electrochemical DNA biosensor for the determination of benzo[a]pyrene-DNA adducts. Anal. Chim. Acta 2001, 450, 45-52.