Xiao-an Zhang

Academic Title: Assistant Professor

Phone: 416-287-7202

Office: SW511

Email:

Research Homepage:

Our research interests span across the interface of molecular imaging, neurobiology, medicinal chemistry, molecular recognition and biomimetic chemistry. The current research focus in our lab includes the rational design, synthesis, characterization and application of (1) MRI and fluorescence sensors for imaging brain activity, (2) multi-modality chemical agents for noninvasive disease diagnosis and treatment, and (3) bio-inspired supramolecular receptors/catalysts.

1. Xiao-an Zhang, Dugan Hayes, Sarah J. Smith, Simone Friedle, Stephen J. Lippard, New Strategy for Quantifying Biological Zinc by a Modified Zinpyr Fluorescence Sensor. J. Am. Chem. Soc., 2008, 130(47), 15788-15789
2. Xiao-an Zhang, Datong Song, Stephen J. Lippard, A Reversible pH-Dependent Intramolecular Pyridine-Aldehyde Cyclization. J. Org. Chem., 2008, 73(2), 734-737.
3. Xiao-an Zhang, Katherine Lovejoy, Alan Jasanoff, Stephen J. Lippard, Water-Soluble Porphyrins as a Dual-Function Molecular Imaging Platform for MRI and Fluorescence Zinc Sensing. Proc. Natl. Acad. Sci. USA, 2007, 104(26), 10780-10785 (Highlighted in ChemTract, 2007, 20, 395).
4. Xiao-an Zhang, Wolf-D Woggon, From the First Fluorescent Sensor of Pyrovanadate to the Functional Model of Vanadium Haloperoxidase. J. Am. Chem. Soc., 2005, 127(41), 14138-14139.
5. Xiao-an Zhang, Markus Meuley, Wolf-D Woggon, The First Supramolecular Receptor of Orthovanadate: Towards Mimics of Vanadium Haloperoxidase. J. Inorg. Biochem., 2004, 98(11), 1967-1970.