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Alex Harrison

Alex Harrison

Academic Title: Emeritus Professor

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Research

Our research is concerned with fundamental and applied studies in gas-phase ion chemistry and with the analytical applications of mass spectrometry. A long-term interest has been the study of gas-phase ion/molecule reactions which has led, over the past thirty years, to extensive fundamental and applied studies in chemical ionization mass spectrometry, the ionization of the analyte by gas-phase ion/molecule reactions. This has led to the publication of the monograph Chemical Ionization Mass Spectrometry (CRC Press, 1983, Second Edition 1992). Another area of interest has been the study, both experimentally and by ab initio calculations, of the structures and fragmentation reactions of gaseous ions. More recently, these studies have been concerned with detailed mechanisms for the fragmentation of protonated or deprotonated peptides, with the ultimate aim of furthering the use of mass spectrometry in elucidating the amino acid identity and sequence in peptides through collision-induced fragmentation of the ionized species.

Selected Publications

A.G. Harrison, A.B. Young, C. Bleiholder, S. Suhai and B. Paizs, Scrambling of Sequence Information in Collision-induced Dissociation of Peptides, J. Am. Chem. Soc. 128 , 10364-10365 (2006).

A.G. Harrison and A.B. Young, Fragmentation Reactions of Deprotonated Peptides Containing Aspartic Acid. Int. J. Mass Spectrom. 255 , 111-122 (2006).

A.G. Harrison, Structural and Sequence Effects in the Fragmentation of Protonated Tripeptides Containing Tyrosine. Can. J. Chem. 83 , 1969-1977 (2005).

A.G. Harrison and A.B. Young, Fragmentation Reactions of Deprotonated Peptides Containing Proline. The Proline Effect. J. Mass Spectrom. 40 , 1173-1186 (2005).

A.G. Harrison, A.B. Young, M. Schnoelzer and B. Paizs, Formation of Iminium Ions by Fragmentation of a 2 Ions. Rapid Commun. Mass Spectrom. 18 , 1635-1640 (2004).

B. Paizs, M. Schnoelzer, U. Warnken, S. Suhai and A.G. Harrison, Cleavage of the Amide Bond of Protonated Dipeptides. Phys. Chem. Chem. Phys. 6 , 2691-99 (2004).

R.N. Grewal, H. El Aribi, A.G. Harrison, K.W.M. Siu and A.C. Hopkinson, Fragmentation of Protonated Tripeptides. The Proline Effect Revisited. J. Phys. Chem. B 108 , 4899-4908 (2004)

G.A. Chass, C.N.J. Marai, D.H. Setiadi, I.G. Csizmadia and A.G. Harrison, A Hartree-Fock, MP2 and DFT Computational Study of the Structures and Energies of "b 2 Ions Derived from Deprotonated Peptides. A Comparison of Method and Basis Set Used on Relative Product Stabilities. J. Molec. Struct. (THEOCHEM) 675 , 149-162 (2004).

A.G. Harrison, Fragmentation Reactions of Protonated Peptides Containing Glutamine or Glutamic Acid. J. Mass Spectrom. 38 , 174-187 (2003)