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J. Bryan Jones

J. Bryan Jones

Academic Title: Emeritus University Professor


Research Homepage: http://www.chem.utoronto.ca/staff/JBJ/


Bioorganic and enzyme chemistry - see Research Home Page

Selected Publications

  • Phillip M. Rendle, Andreas Seger, Joao Rodrigues, Neil J. Oldham, Richard R. Bott, J. Bryan Jones, Marjorie M. Cowan, and Benjamin G. Davis, Glycodendriproteins: A Synthetic Glycoprotein Mimic Enzyme with Branched Sugar-Display Potently Inhibits Bacterial Aggregation, J. Am. Chem. Soc., 126 , 4750-4751 (2004)
  • B.G. Davis, R.F. Sala, D.A. Hodgson, A. Ullman, K. Khumatveeporn, D.A. Estell, K. Sanford, R.R. Bott and J.B. Jones, Selective Protein Degradation by Ligand-Targeted Enzymes: Towards the Creation of Catalytic Antagonists, ChemBioChem, 4 , 457, 533-537 (2003)
  • K. Matsumoto, B. G. Davis and J. B. Jones, Chemically Modified “Polar Patch” Mutants of Subtilisin in Peptide Synthesis with Remarkably Broad Substrate Acceptance: Designing Combinatorial Biocatalysts, Chem. Eur. J., 8 , 4129-4137 (2002)
  • G. DeSantis and J.B. Jones, “Combining Site-Specific Chemical Modification with Site-Directed Mutagenesis: A Versatile Strategy To Move Beyond the Structural Limitations of the 20 Natural Amino Acids Side Chains in Protein Engineering”, in ‘In Vitro Mutagenesis Protocols' , Methods in Molecular Biology, Humana Press, 2002, vol 182, pp55-65
  • Expanding the Utility of Proteases in Synthesis: Broadening the Substrate Acceptance in Non-Coded Amide Bond Formation Using Chemically Modified Mutants of Subtilisin, K. Khumtaveeporn, A. Ullman, K. Matsumoto, B.G. Davis and J.B. Jones, Tetrahedron Asymmetry , 2001, 12 , 249-261.
  • Glycosylation of the Primary Binding Pocket of a Protease causes a remarkable broadening in Stereospecificity in Peptide synthesis, K. Matsumoto, B.G. Davis and J.B. Jones, Chem. Commun. , 2001, 903-904
  • Controlled Site-Selective Glycosylation for Precise Glycan Structure-Catalytic Activity Relationships, B. G. Davis, R. C. Lloyd, and J. B. Jones, Bioorg. Med. Chem ., 2000, 8 , 1527-1535.
  • Site-Selective Glycosylation of Subtilisin Bacillus lentus Causes Dramatic Increases in Esterase Activity, R. C. Lloyd, B. G. Davis, and J. B. Jones, Bioorg. Med. Chem. , 2000, 8, 1537-1544.
  • Benzophenone Boronic Acid Photoaffinity Labeling of Subtilisin CMMs to Probe Altered Specificity, G. DeSantis, C.Paech, and J. B. Jones, Bioorg, Med. Chem. , 2000, 8 , 563-570.
  • Structure-Based Design Guides the Improved Efficacy of Deacylation Transition State Analog Inhibitors of TEM-1 beta–Lactamase, S. Ness, R. Martin, A. M. Kindler, M. Paetzel, M. Gold, S. E. Jensen, J. B. Jones, and N. C. J. Strynadka, Biochemistry , 2000, 39 , 5312-5321.