We search for general strategies for the photo-control of peptide and protein structure – and thereby activity. In doing so, we gain fundamental knowledge about protein conformation, folding, and dynamics. We also develop powerful tools for the analysis of complex biochemical systems. To learn more about our exciting research in photoswitchable protein engineering click here
We found that introducing azobenzene-based cross-linkers to proteins allows for the control of protein folding and function using light. In addition to modifying proteins with azobenzenes to make them photoswitchable we also develop new azobenzenes with improved properties for applications in vivo. To learn more about exciting developments in azobenzene-based photoswitches click here
Equipment is readily available for everything from small molecule synthesis (NMR, mass spectrometry, X-ray, HPLC) to protein production (autoclaves, incubators, FPLC, electrophoresis, centrifuges) to analysis (fluorescence, CD, various types of UV/Vis, high field NMR).