William F. Reynolds
Professor -- Physical Chemistry
Lash Miller Chemical Laboratories
80 St. George St.
University of Toronto
Toronto, Ontario, Canada M5S 1A1
Office: Lash Miller, Room 147
Nuclear magnetic resonance spectroscopy is probably the single most
widely-used spectroscopic method with applications from Physics to Medicine.
Our research concentrated on development of improved methodology for NMR
specifically in the area of multi-dimensional NMR. There are three main
aspects of this work. The first involves the development of improved
multi-dimensional NMR pulse sequences, specifically for structure
elucidation (e.g. see reference 1). The second involves the fundamental
understanding of these sequences and particularly the circumstances under
which unexpected peaks may be generated (e.g. see reference 2). The third
involves the development of `artificial intelligence' software for
multi-dimensional NMR in which the spectrometer computer is programmed to
pose a series of questions to the user, and based on the answers to these
questions, chooses the optimum parameters for the particular experiment.
This is designed to make the extremely powerful new NMR techniques more
accessible to users who are not highly trained spectroscopists.
- K.A. Carpenter, W.F. Reynolds, J.P. Yang and R.G. Enriquez,
Further Improvement in the FLOCK Sequence,
Magn. Reson. Chem., 1992, 30, 535.
- A.D. Bain, I.W. Burton and W.F. Reynolds,
Artifacts in Two-Dimensional NMR,
Prog. NMR Spectroscopy, 1994, 26, 59-89.
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Created July 31, 1995. Last updated December 12, 1995.