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Welcome to the Nitz Lab website!

We study a range of topics in bio-organic chemistry and chemical biology.

Welcome to Nitz Lab

Announcements

A round of applause for Master Amanda who completed her M.Sc. exit seminar on desulfurative cross-coupling of thioglycosides! Your hard work has set a high bar for excellence in our lab. Well done!*pictured is Amanda's pet snake Ruby 🐍

Our new paper presents how N-azidoacetylglucosamine (GlcNAz) can be incorporated into bacterial peptidoglycan for metabolic labeling in Escherichia coli. By the expression of NahK in E. coli, the cytosolic production of UDP-GlcNAz and preferential incorporation into peptidoglycan (PGN) over other sites like poly-β-1,6-N-acetylglucosamine (PNAG), lipopolysaccharide (LPS), or enterobacterial...

See our recent publication (starred with Editor's Choice⭐) on designing and implementing the first mass cytometry ligands compatible with the HaloTag system. Employing "click"-amenable HaloTag warheads conjugated metal-chelating polymers, we demonstrated successful labelling of HEK293T cells. https://doi.org/10.1021/acs.bioconjchem....

Our newest publication offers a promising addition to the toolbox of bioorthogonal reactions in chemical biology! We present a cascade reaction between N-allylglyoxylamide and N-alkylhydroxylamine, catalyzed by 5-methoxyanthranilic acid, combining the reactivity of nitrones with the simplicity of aldehydes, demonstrating bioorthogonality in complex cell lysates and on the surface of HEK293...

As the holidays approach, the Nitz group is donning up with festivity ❄️ We present to you... The Coatmas Tree! Transforming perished lab coats into a festive decoration, we are embracing the holiday cheer with a dash of science and sustainability.

Contact Info

Department of Chemistry
University of Toronto
80 St. George St.
Toronto, Ontario  M5S 3H6
Canada  
 
Email: mark.nitz@utoronto.ca
Phone:  (416) 946-0639
Room:  LM 459 (Davenport wing)