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Selected Publications

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Structural and functional analysis of de-N-acetylase PgaB from periodontopathogen Aggregatibacter actinomycetemcomitans.

Parthiban C, Varudharasu D, Shanmugam M, Gopal P, Ragunath C, Thomas L, Nitz M, Ramasubbu N. 2016 Oct 5. doi: 10.1111/omi.12175


Isotopologous Organotellurium Probes Reveal Dynamic Hypoxia In Vivo with Cellular Resolution.

Edgar LJ, Vellanki RN, McKee TD, Hedley D, Wouters BG, Nitz M.Angew. Chem. Int. Ed.. 2016 Oct 10;55(42):13159-13163


Access to Versatile β-Cyclodextrin Scaffolds through Guest-Mediated Monoacylation.
Vurgun N, Gómez-Biagi RF, Nitz M. Chemistry. 2016 Jan;22(3):1062-9


The protein BpsB is a poly-β-1,6-N-acetyl-D-glucosamine deacetylase required for biofilm formation in Bordetella bronchiseptica.
Little DJ, Milek S, Bamford NC, Ganguly T, DiFrancesco BR, Nitz M, Deora R, Howell PL. J Biol Chem. 2015 Sep 11;290(37):22827-40


Organotellurium scaffolds for mass cytometry reagent development.
Park H, Edgar LJ, Lumba MA, Willis LM, Nitz M. Org Biomol Chem. 2015 Jul 7;13(25):7027-33


Direct Staudinger-Phosphonite Reaction Provides Methylphosphonamidates as Inhibitors of CE4 De-N-acetylases.
Ariyakumaran R, Pokrovskaya V, Little DJ, Howell PL, Nitz M. Chembiochem. 2015 Jun 15;16(9):1350-6


Structural basis for the De-N-acetylation of Poly-β-1,6-N-acetyl-D-glucosamine in Gram-positive bacteria.
Little DJ, Bamford NC, Pokrovskaya V, Robinson H, Nitz M, Howell PL. J Biol Chem. 2014 Dec 26;289(52):35907-17


Identification of hypoxic cells using an organotellurium tag compatible with mass cytometry.
Edgar LJ, Vellanki RN, Halupa A, Hedley D, Wouters BG, Nitz M. Angew Chem Int Ed Engl. 2014 Oct 20;53(43):11473-7


Modification and periplasmic translocation of the biofilm exopolysaccharide poly-β-1,6-N-acetyl-D-glucosamine.
Little DJ, Li G, Ing C, DiFrancesco BR, Bamford NC, Robinson H, Nitz M, Pomès R, Howell PL. Proc Natl Acad Sci U S A. 2014 Jul 29;111(30):11013-8


Functional PEG-PAMAM-tetraphosphonate capped NaLnF₄ nanoparticles and their colloidal stability in phosphate buffer.
Zhao G, Tong L, Cao P, Nitz M, Winnik MA. Langmuir. 2014 Jun 17;30(23):6980-9


A high-sensitivity lanthanide nanoparticle reporter for mass cytometry: tests on microgels as a proxy for cells.
Lin W, Hou Y, Lu Y, Abdelrahman AI, Cao P, Zhao G, Tong L, Qian J, Baranov V, Nitz M, Winnik MA. Langmuir. 2014 Mar 25;30(11):3142-53


Protecting-group-free O-glysosidation using p-toluenesulfonohydrazide and glycosyl chloride donors.
Williams RJ, Paul CE, Nitz M. Carbohydr Res. 2014 Mar 11;386:73-7


Functional characterization of Staphylococcus epidermidis IcaB, a de-N-acetylase important for biofilm formation.
Pokrovskaya V, Poloczek J, Little DJ, Griffiths H, Howell PL, Nitz M.
Biochemistry. 2013 Aug 13;52(32):5463-71


Improving lanthanide nanocrystal colloidal stability in competitive aqueous buffer solutions using multivalent PEG-phosphonate ligands.
Cao P, Tong L, Hou Y, Zhao G, Guerin G, Winnik MA, Nitz M. Langmuir. 2012 Sep 4;28(35):12861-70


Aβ(1-42) assembly in the presence of scyllo-inositol derivatives: identification of an oxime linkage as important for the development of assembly inhibitors.
Shaw JE, Chio J, Dasgupta S, Lai AY, Mo GC, Pang F, Thomason LA, Yang AJ, Yip CM, Nitz M, McLaurin J. ACS Chem Neurosci. 2012 Mar 21;3(3):167-77


Synthesis and evaluation of inhibitors of E. coli PgaB, a polysaccharide de-N-acetylase involved in biofilm formation.
Chibba A, Poloczek J, Little DJ, Howell PL, Nitz M. Org Biomol Chem. 2012 Sep 21;10(35):7103-7


Syntheses of carbocyclic analogues of α-D-glucosamine, α-D-mannose, α-D-mannuronic acid, β-L-idosamine, and β-L-gulose.
Sun Y, Nitz M. J Org Chem. 2012 Sep 7;77(17):7401-10


Protecting-group-free synthesis of glycosyl 1-phosphates.
Edgar LJ, Dasgupta S, Nitz M. Org Lett. 2012 Aug 17;14(16):4226-9


The structure- and metal-dependent activity of Escherichia coli PgaB provides insight into the partial de-N-acetylation of poly-β-1,6-N-acetyl-D-glucosamine.
Little DJ, Poloczek J, Whitney JC, Robinson H, Nitz M, Howell PL. J Biol Chem. 2012 Sep 7;287(37):31126-37


Combining in situ proteolysis and mass spectrometry to crystallize Escherichia coli PgaB.
Little DJ, Whitney JC, Robinson H, Yip P, Nitz M, Howell PL. Acta Crystallogr Sect F Struct Biol Cryst Commun. 2012 Jul 1;68(Pt 7):842-5


Site-selective affinity labelling of maltose binding protein in bacterial cells.
Rullo A, Beharry AA, Gómez-Biagi RF, Zhao X, Nitz M. Chembiochem. 2012 Apr 16;13(6):783-7


In vivo uptake of β-amyloid by non-plaque associated microglia.
Hawkes CA, Deng L, Fenili D, Nitz M, McLaurin J. Curr Alzheimer Res. 2012 Oct;9(8):890-901


Characterization of the poly-β-1,6-N-acetylglucosamine polysaccharide component of Burkholderia biofilms.
Yakandawala N, Gawande PV, LoVetri K, Cardona ST, Romeo T, Nitz M, Madhyastha S. Appl Environ Microbiol. 2011 Dec;77(23):8303-9


Comparisons of [18F]-1-deoxy-1-fluoro-scyllo-inositol with [18F]-FDG for PET imaging of inflammation, breast and brain cancer xenografts in athymic mice.
McLarty K, Moran MD, Scollard DA, Chan C, Sabha N, Mukherjee J, Guha A, McLaurin J, Nitz M, Houle S, Wilson AA, Reilly RM, Vasdev N. Nucl Med Biol. 2011 Oct;38(7):953-9


Sodium/myo-Inositol transporters: substrate transport requirements and regional brain expression in the TgCRND8 mouse model of amyloid pathology.
Fenili D, Weng YQ, Aubert I, Nitz M, McLaurin J. PLoS One. 2011;6(8):e24032


Development of mass cytometry methods for bacterial discrimination.
Leipold MD, Ornatsky O, Baranov V, Whitfield C, Nitz M. Anal Biochem. 2011 Dec 1;419(1):1-8


Mono-acylation of a polyamine-β-cyclodextrin based on guest mediated acyl migration.
Gómez-Biagi RF, Nitz M. Chem Commun (Camb). 2011 Aug 14;47(30):8614-6


Peptide-glycosaminoglycan cluster formation involving cell penetrating peptides.
Rullo A, Qian J, Nitz M. Biopolymers. 2011 Oct;95(10):722-31


Use of N,O-dimethylhydroxylamine as an anomeric protecting group in carbohydrate synthesis.
Dasgupta S, Nitz M. J Org Chem. 2011 Mar 18;76(6):1918-21


Multiplexed protease assays using element-tagged substrates.
Lathia US, Ornatsky O, Baranov V, Nitz M. Anal Biochem. 2011 Jan 1;408(1):157-9


Synthesis of a functional metal-chelating polymer and steps toward quantitative mass cytometry bioassays.
Majonis D, Herrera I, Ornatsky O, Schulze M, Lou X, Soleimani M, Nitz M, Winnik MA. Anal Chem. 2010 Nov 1;82(21):8961-9


Synthesis of a core disaccharide from the Streptococcus pneumoniae type 23F capsular polysaccharide antigen.
Dasgupta S, Nitz M. Carbohydr Res. 2010 Oct 13;345(15):2282-6


Highly multiparametric analysis by mass cytometry.
Ornatsky O, Bandura D, Baranov V, Nitz M, Winnik MA, Tanner S. J Immunol Methods. 2010 Sep 30;361(1-2):1-20


Small molecule beta-amyloid inhibitors that stabilize protofibrillar structures in vitro improve cognition and pathology in a mouse model of Alzheimer’s disease.
Hawkes CA, Deng LH, Shaw JE, Nitz M, McLaurin J. Eur J Neurosci. 2010 Jan;31(2):203-13


Development of inductively coupled plasma-mass spectrometry-based protease assays.
Lathia US, Ornatsky O, Baranov V, Nitz M. Anal Biochem. 2010 Mar 1;398(1):93-8


Importance of the spatial display of charged residues in heparin-peptide interactions.
Rullo A, Nitz M. Biopolymers. 2010 Mar;93(3):290-8