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  1. Cell
    DYSREGULATION OF MITOCHONDRIAL CLPP
    PROTEASE AS A POTENTIAL STRATEGY TO
    DEVELOP NOVEL ANTICANCERS
    Human mitochondrial ClpP was found to be activated by specific
    acyldepsipeptide compounds causing apoptotic cell death.
    Houry and Batey groups, Cell Chemical Biology, 2018
  2. Nature
    AMINE HEMILABILITY ENABLES BORON TO
    MECHANISTICALLY RESEMBLE EITHER
    HYDRIDE OR PROTON
    Mechanistic studies of the hemilability of MIDA
    (N-methyliminodiacetic acid) boronates reveal the chameleonic
    behaviour of the BMIDA group.
    Yudin group, Nature Chemistry, 2018
  3. Nature
    TIPPING CELL SIGNALING PATHWAYS BY SALTS
    Mechanistic insights into allosteric regulation ofthe A2A adenosine
    G protein-coupled receptor byphysiological cations.
    Prosser group, Nature Communications, 2018
  4. Journal of the American Chemical Society
    COMPETITIVE SELF-ASSEMBLY KINETICS AS A
    ROUTE TO CONTROLLING MORPHOLOGY OF
    CORE-CRYSTALLINE CYLINDRICAL MICELLESS
    One can manipulate the seeded-growth kinetics of block
    copolymer unimers to control the growth sequence of
    unimers and thus the comicelle morphology.
    Winnik group, Journal of the American Chemical Society, 2018
  5. Oncogene
    INHIBITING MYC BINDING TO THE E-BOX DNA
    MOTIF BY ME47 DECREASES
    TUMOUR XENOGRAFT GROWTH
    The Shin lab's designed protein ME47 decreased tumor growth in
    a triple negative breast cancer mouse model, a type of cancer with
    no effective treatments.
    Shin, Chan & Penn groups, Oncogene, 2017

Awards:

Professor Mark Taylor wins Horace S. Isbell Award

Professor Mark Taylor wins Horace S. Isbell Award

Professor Mark Taylor is the winner of the 2018 Horace S. Isbell Award for excellence in and promise of continued quality of contribution to research in carbohydrate chemistry and biochemistry.

Mark is being recognized for his research in carbohydrate chemistry, particularly his work in developing catalysts that are able to activate sugars towards reactions at specific positions. These catalysts can be used to streamline the synthesis of complex, sugar-containing molecules.


News and Announcements:

Meet 2018 Vanier Scholar Karen Morenz

Meet 2018 Vanier Scholar Karen Morenz

Karen Morenz, a 3rd year PhD student in the Wilson Lab, is one of nine 2018 NSERC Vanier Scholars from the University of Toronto.

This award recognizes Karen's academic excellence, research potential and leadership.





Professor Molly Shoichet: Basic research 'at the root' of innovation in Canada

Professor Molly Shoichet: Basic research 'at the root' of innovation in Canada

Professor Molly Shoichet spoke at a recent Economic Club of Canada panel discussion in support of funding basic research.

“It’s really important to recognize that research is at the root of innovation and commercialization,” Shoichet said. “If you don’t invest in that research, we won't have those innovations and there won't be anything to commercialize.”


Remembering Alex Harrison

Remembering Alex Harrison

Professor Emeritus Alex Harrison will be remembered as a passionate chemist who changed the landscape of gas-phase ion chemistry and mass spectrometry. Harrison, who joined the department of chemistry in 1959, died on September 7 at the age of 87.

“Alex was a remarkable individual, an outstanding chemist, and a devoted and respected member of our department and the university,” said Rob Batey, professor and chair of the department of chemistry.


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Latest Covers:

Acyldepsipeptide Analogs Dysregulate Human Mitochondrial ClpP Protease Activity and Cause Apoptotic Cell Death
Acyldepsipeptides (ADEPs) are potential antibiotics that dysregulate the activity of the highly conserved tetradecameric bacterial ClpP protease, leading to bacterial cell death. Here, we identified...

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