Academic Title: Associate Professor (Cross Appointed), Institute of Biomaterials and Biomedical Engineering
Office: CCBR 408
Research Homepage: http://inbs.med.utoronto.ca/
The Chan Research Group aims to develop and applying nanomaterials for improving the diagnosis of cancer and infectious diseases, two of the leading causes of death in the world. We utilize the distinct properties associated with nanomaterials (e.g., quantum dots, metal nanoparticles) to engineer contrast agents and delivery vehicles for targeting disease-relevant molecules, cells, organs, and tissues both in vitro and in vivo. Researchers in the lab acquire a broad range of skills, including nanomaterial design, polymer synthesis, cell culturing, and growing animal tumor models.
S. D. Perrault, C. Walkey, T. Jennings, H.C. Fischer, W. C. W. Chan, "Mediating Tumor Targeting Efficiency of Nanoparticles through Design," Nano Letters, 2009, 9, 1905.
W. Jiang, B. Y. Kim, J. T. Rutka, W.C.W. Chan, "Size selective mechanism governs engineered nanoparticle-induced membrane receptor trafficking," Nature Nanotechnology, 2008, 3, 145.
J. M. Klostranec, Q. Xiang, G. A. Farcas, J. A. Lee, A. Rhee, E. I. Lafferty, S. D. Perrault, K. C. Kain, W. C. W. Chan, "Convergence of Quantum Dot Barcodes with Microfluidics and Signal Processing for Multiplexed High-Throughput Infectious Disease Diagnostics," Nano Letters 2007, 7, 2812.
A. Ghazani, J. A. Lee, J. Klostranec, Q. Xiang, R. Da Costa, B. C. Wilson, M. Tsao, W.C.W. Chan, "High Throughput Quantification of Protein Expression of Cancer Antigens in Tissue Microarray using Quantum Dot Nanocrystals," Nano Letters, 2006, 6, 2881. Highlighted in Science (2006, 314, 1661)
H. Fischer, L. Li, K.S. Pang and W.C.W. Chan, "Pharmacokinetics of Nanoscale Quantum Dots: In Vivo Distribution, Sequestration, and Clearance in Rats," Advanced Functional Materials, 2006, 16, 1299.